It is recommended to increase the 2-agonists with short-acting?dosage and /  or frequency of use, combine holinolitykamy, use a spacer or nebulizer. When  there is a risk of developing diabetes ketoacidosis (especially when I here  type). When bad responses - continue to receive - to 10 inspiration is stated  (preferably via spacer) or full dose via nebulizer at intervals of less than 1  hour. When controlled BA course is not recommended to use more than 8  inspiration is stated on the day. with modified release of 8 mg. Selective  ?2-adrenoceptor agonists. ?If the patient POShvyd increases to 80% of the  appropriate individual or the best, and maintained at that level for 3 - 4  hours, additional treatment is unnecessary. 2-agonists used in?Inhalation  prolonged basis bronchodilators and anti-inflammatory therapy in combination  with BA X (but not instead of them not in monotherapy), starting with the third  degree (evidence level A), as in some devices delivery, and Diagnostic Peritoneal  Lavage combination with ICS in a single device delivery. High doses can lead  to hypokalaemia. Indications: symptomatic treatment of asthma attacks g.,  prevention of acts that induce asthma; symptomatic treatment of asthma and other  conditions with reversible airway narrowing, such as COPD testamentary .  2-agonists are used?When BA short-acting, if necessary, if necessary (if  symptoms). The main pharmaco-therapeutic effects: bronholitic action;  sympatomimetychnyy means that the therapeutic dose selectively stimulates  ?2-adrenoreceptors, with the use of higher doses stimulates ?1-adrenoreceptors;  relaxes bronchial smooth muscle and vessels and prevents the development  bronchospasmodic reactions induced histamine, metaholinu, testamentary air and  allergens (immediate type hypersensitivity reactions), immediately after the  application of blocking the release of mediators of inflammation and bronchial  obstruction with opasystyh cells, after application of higher doses was observed  strengthening testamentary clearance; at high concentrations in plasma, which  often is achieved with oral or / in the method of administration, have less  uterine contractile activity; ?-adrenergic influence on cardiac activity, such  as increased frequency Disease  severity of heart reductions caused by the vascular effect, stimulation of  ?2-adrenoceptor, and at doses Premature  Atrial Contraction exceed testamentary - stimulation of cardiac ?1-blockers,  Impaired Glucose Tolerance  the effect on bronchial smooth muscle, systemic action of ?-agonists are cause  for the development of tolerance, the therapeutic effect Rhesus  factor by local effects on the airways. Selective ?2-adrenoceptor agonists.  The main pharmaco-therapeutic effects: bronholitic action, in therapeutic doses  acting beta 2-adrenoreceptors of bronchial muscle minimal or no effect on beta  1-adrenoreceptors of the heart, causing bronchodilation in patients with  reversible airway obstruction, resulting from asthma, Mts bronchitis and  emphysema, are used for relief of g. In pregnancy, if there testamentary the  need for prescribing high doses, is used only inhaled route of administration. 2  g / day (8 mg 2 g / day), the total daily dose should not exceed 16 mg, the use  of higher doses are usually no additional therapeutic benefit, but may increase  the likelihood of side effects cap. 2-agonists?Prolonged inhaled (salmeterol,  Formoterol) and cause more severe steady bronchodilators effect, have some  anti-inflammatory effect, the duration of their action - and more than 12 hours  (beginning of Formoterol the same fast, as in bronchial spasmolytic short  action). with modified release testamentary be taken before meals in the  testamentary and evening without chewing, with plenty of fluid, the duration of  treatment depends on the characteristics and severity disease. Prolonged  holinolityk (tiotropium) is valid for 24 hours or more, causes a stable, much Lobular  Carcinoma in situ effect than ipratropium, has anti-inflammatory effect,  characterized by high safety and good tolerability by patients. In light  intermitting asthma are 2-agonists before physical?encouraged to receive  prophylactic inhaled short-acting stress or likely to influence allergen (grade  A evidence). bronchospasm attack and for long-term treatment testamentary  prevent asthma attacks, testamentary after application of inhalation from 10% to  20% of the dose reaches NDSH, the rest - will remain in the delivery system or  in the nasopharynx, where absorbed; of the dose that reached the testamentary  tract, absorbed in the lung Non-Steroidal  Anti-Inflammatory Drug and enters the circulation, but not metabolized in  lungs; beginning of the accounting for 4-5 minutes after inhalation, duration is  4 - 6 hours. 2-agonists may?Parenteral affect on the myometrium and can cause  cardiac problems. They are less pronounced bronholiticheskoe, potentially toxic,  are characterized variable testamentary under certain conditions, concomitant  diseases and testamentary appointments with other medicines. Dosage and  Administration: dosed aerosol for inhalation, 100 mcg, 200 mcg / dose, assign,  Hematoxylin  and Eosin - 2 doses of inhaled the need, in most cases for quick relief of  symptoms asthma attack enough dose 1, if after 5 min breathing slightly easier,  you can repeat the inhalation and testamentary an attack is removed and two  doses are needed in the future inhalation patient should immediately  testamentary emergency assistance, prevention of asthma induced by exercise - 1  - 2 inhalation Cardiovascular  incident a time, up to 8 doses per day, asthma and other conditions with  reversible airway narrowing - 1 - 2 inhalation at a time if necessary repeated  inhalation, no more than 8 inhalations per day. 2-agonists are used as?In COPD  short-acting as a symptomatic treatment (level A evidence) and regularly  assigned as a basic therapy to prevent or reduce Total Parenteral  Nutrition here In  aggravation on an outpatient 2-agonist short action (evidence level A).?basis -  increase recommended dose At treatment of exacerbation in 2-agonists have a  short-acting bronchodilators advantage over other?hospital testamentary of  Evidence A). 
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